报告题目：Transforming Rradiotherapy From a Localized to Systemic Therapy
报告人：Amato J. Giaccia，Ph.D.
Jack, Lulu & Sam Willson Professor in Cancer Biology
Associate Director of Basic Science, Stanford Cancer Institute
Associate Chair for Research
Director, Division of Radiation & Cancer Biology
Department of Radiation Oncology
Dr. Giaccia’s research is focused on translating basic science findings on the role of hypoxia in tumor progression and resistance to therapy to pre-clinical models of cancer that he ultimately hope to take into the clinic. The overarching hypothesis of his research is that hypoxia not only makes tumor cells resistant to radiotherapy, chemotherapy and in some cases targeted therapy, but also increases their invasiveness and metastatic potential by inducing a selected group of genes involved in tissue remodeling. His laboratory is rigorously investigating the genomic response of tumor cells to hypoxia and developing new targeted therapies to eliminate hypoxic cells or inhibit the secreted gene products of hypoxic cells that drive malignant progression and metastasis. He has advanced understanding of gene regulation under hypoxic conditions, used synthetic lethal screening to identify new targets for hypoxia directed therapies, and are developing new diagnostics for hypoxia. His future goals will be to further define critical effectors of the hypoxic response that are essential for tumor growth and expansion that can be targeted therapeutically.Dr. Giaccia was awarded an American Cancer Society Junior Faculty Research Award, Howard Hughes Junior Faculty Research Award, and the Michael Fry Award from the Radiation Research Society for outstanding contributions on understanding the molecular mechanisms of resistance promoted by the tumor microenvironment. Additionally, he was the recipient of the 2013 ASTRO Gold Medal. In 2015, he was awarded a NIH R35 Outstanding Investigator Award and was inducted into the National Academy of Medicine. He has published over 275 peer-reviewed manuscripts and co-authored the sixth & seventh editions of the textbook, “Radiation Biology for the Radiologist,” with Professor Eric Hall from Columbia.