学部概况
教师队伍
人才培养
学院、部
临床医院
科学研究
管理服务
交流合作
北医产业
ENGLISH
 
 
 
 招生就业
 招聘信息
 校园文化
 服务平台
 校内信息
 信息周刊
首页 >> 学术讲座 >>

(9月20日)北京大学基础医学院院长论坛
发布日期:2017-09-15 浏览次数: 字号:[ ]

  报告题目:Tuning T cell responses.

  报告人:Dr. Avery August

  Professor and Chair

  Department of Microbiology and Immunology

  College of Veterinary Medicine, Cornell University

  时间:2017年9月20日(星期三)上午10:00

  地点:生化楼3层中厅

  主持人:吴聪颖研究员

  报告简介:

  The August laboratory is interested in signals that regulate the choices that immune cells make in deciding to respond in an inflammatory or suppressive manner. We study these signals in the context of allergy and lung inflammation, using mouse genetic models and human cells. Specifically, we study a family of tyrosine kinases expressed by immune cells, the Tec family kinases, that regulate immune cell activation. Although these kinases are expressed in different immune cells such as T and B cells, and mast cells, their response to extracellular stimuli are different. Using mouse genetic models, we have found that the major Tec kinase expressed in T cells, Itk, positively regulates the differentiation of CD4+ T cells (Th2, Th17), or suppressor (Tr1 cells), but negatively regulates the development of Foxp3+Treg cells. This tuning of T cell differentiation by Itk controls whether the immune response is inflammatory (such as in lung inflammation or allergy), or suppressive (such as the production of IL10 by Tr1 cells).  In CD8+ T cells, we have shown that Itk is a negative regulator of different memory populations, including innate memory and antigen-induced memory CD8+ T cells. Our work suggest that Itk is a critical node in tuning the T cell response towards inflammation or suppression.

  

  欢迎各位老师及同学参加!




打印本页 关闭窗口

版权所有:北京大学医学部 北京市海淀区学院路38号  邮编:100191  京ICP备05065075号-19