报告题目：New signaling and trafficking pathways in polarized epithelial cells
报告人：Michael J. Caplan M.D., Ph.D., C.N.H. Long Professor of Cell Biology
Chair, Department of Cellular and Molecular Physiology
Yale University School of Medicine
Michael J. Caplan is the C.N.H. Long Professor and Chair of the Department of Cellular and Molecular Physiology and Professor of Cell Biology at the Yale University School of Medicine. He earned his undergraduate degree from Harvard University in 1980, and his M.D. and Ph.D. degrees from Yale University in 1987. He joined Yale’s Department of Cellular and Molecular Physiology as a faculty member in 1988. He has received fellowships from the Helen Hay Whitney Foundation, the David and Lucille Packard Foundation for Science and Engineering and a National Young Investigator Award from the National Science Foundation. He has received the Young Investigator Awards from the American Physiological Society and the American Society of Nephrologists, and has delivered the American Physiological Society’s Carl W. Gottschalk Distinguished Lectureship. He has been elected to membership in the American Association of Physicians and has received Yale University School of Medicine’s Bohmfalk Prize for teaching. His scientific work focuses on understanding the ways in which epithelial cells communicate to maintain their unique structures. His laboratory also studies Autosomal Dominant Polycystic Kidney Disease, a prevalent and serious genetic disorder and a major cause of kidney failure. The Caplan laboratory is working to understand the mechanisms responsible for this condition and to identify targets for new therapies.
1. Merrick, D.M., H.C. Chapin, Z. Yu, S. Somlo, J. Hogenesch, and M.J. Caplan(2012). The gamma-secretase cleavage product of Polycystin-1 regulates Tcf and CHOP-mediated transcriptional activation through a p300-dependent mechanism. Dev. Cell, 22, 197–210.
2. Takiar, V., S. Nishio, J.D. King Jr., H. Li, L. Zhang, A. Karihaloo, K.R. Hallows, S. Somlo, M.J. Caplan(2011). Activating AMPK slows renal cystogenesis. Proc. Nat. Acad. Sci, 108:2462-2467.
3. Farr, G.A., M. Hull, I.S. Mellman and M.J. Caplan(2009). Membrane Proteins Follow Multiple Trafficking Pathways to the Basolateral Cell Surface in Polarized Epithelial Cells. J. Cell Biol., 186:269-282.
4. Chauvet, V., X. Tian, H. Husson, D.H. Grimm, T. Wang, T. Hieseberger, P. Igarashi, A.M. Bennett, O. Ibraghimov-Beskrovnaya, S. Somlo and M.J. Caplan(2004).Mechanical stimuli induce the cleavage and nuclear translocation of the polycystin-1 C-terminus. J. Clin. Invest. 114: 1433-1443.