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北京大学基础医学院院长论坛
发布日期:2016-06-29 浏览次数: 字号:[ ]

  报告题目:Novel Regulators and Mechanisms in Tumor Suppression

  报告人:Prof. Wei Gu

  Abraham and Mildred Goldstein endowed chair Professor

  Vice-Chairman for Cancer Research

  Department of Pathology and Cell Biology, Institute for Cancer Genetics

  Columbia University

  时    间:2016年7月8日(星期五)下午2:00

  地    点:医学部生化楼三层中厅

  主持人:尹玉新院长

  

  报告人简介:

  Dr. Gu is recognized internationally for the pioneering contributions to the regulation of p53-mediated tumor suppressor function. His lab has made several seminal discoveries in the area of protein modifications and tumor suppression. For example, he identified the first non-histone protein (p53) that can be regulated by acetylation and deacetylation; his studies of p53 acetylation laid the foundation for the current view that reversible acetylation is a general mechanism for regulation of non-histone proteins. Likewise, following his discovery of a deubiquitinase HAUSP-mediated stabilization of the p53 and Mdm2 polypeptides, deubiquitination has come to be accepted as a common mechanism of protein stabilization.   More recently, his work on metabolic regulation elucidates that p53-mediated tumor suppression can act in the absence of the classic tumor suppression mechanisms including cell-cycle arrest, apoptosis and senescence. Notably, his team has discovered a new mode of tumor suppression based on p53 regulation of cystine metabolism, ROS responses and ferroptosis. He has published more than 20 papers in Cell, Nature and Science.




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