报告题目：Novel Regulators and Mechanisms in Tumor Suppression
报告人：Prof. Wei Gu
Abraham and Mildred Goldstein endowed chair Professor
Vice-Chairman for Cancer Research
Department of Pathology and Cell Biology, Institute for Cancer Genetics
Dr. Gu is recognized internationally for the pioneering contributions to the regulation of p53-mediated tumor suppressor function. His lab has made several seminal discoveries in the area of protein modifications and tumor suppression. For example, he identified the first non-histone protein (p53) that can be regulated by acetylation and deacetylation; his studies of p53 acetylation laid the foundation for the current view that reversible acetylation is a general mechanism for regulation of non-histone proteins. Likewise, following his discovery of a deubiquitinase HAUSP-mediated stabilization of the p53 and Mdm2 polypeptides, deubiquitination has come to be accepted as a common mechanism of protein stabilization. More recently, his work on metabolic regulation elucidates that p53-mediated tumor suppression can act in the absence of the classic tumor suppression mechanisms including cell-cycle arrest, apoptosis and senescence. Notably, his team has discovered a new mode of tumor suppression based on p53 regulation of cystine metabolism, ROS responses and ferroptosis. He has published more than 20 papers in Cell, Nature and Science.